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Clinical Topic Hub

Longevity & Brain Health

Clinical Intelligence Hub • Expert Curation

Preserving cognitive function and neurovascular integrity is essential for long-term healthspan. We analyze publications exploring cellular neuroprotection, synaptic density, and biological interventions that support mental stamina, memory preservation, and brain age deceleration.

How Chronic Pain and Frailty Are Genetically Linked

Discover how new genetic research reveals a bidirectional chronic pain and frailty link, transforming how we understand and measure biological aging.

Cortical Neuromodulation and Neural Connectivity Markers in Tobacco Dependency

Discover how neuromodulation for addiction targets distinct brain networks, and learn why high baseline cravings predict better clinical response to rTMS.

Senolytic Side Effects: The Surprising Risks of Dasatinib and Quercetin

Understand the newly discovered senolytic side effects of dasatinib and quercetin, including how this popular combination risks damaging healthy brain cells.

Healthy Brain Aging: Why Do Some Brains Resist Decline?

Discover how healthy brain aging splits into two distinct biological pathways, revealing new genetic keys to track and optimize your cognitive lifespan.

Why Does Alzheimers Disease Affect More Women? Female Risk Explained

Discover how the XIST gene regulator drives Alzheimer's disease female risk through a newly identified epigenetic feedback loop inside brain cells.

Can Vigorous Physical Activity Activate Longevity Genes to Slow Cellular Aging?

How an AI deep-learning model recovers the exercise signals plain genetics misses, and links the longevity gene CTSF to the cell's waste-clearance system.

Human Brainstem Atlas: How 3D Brain Mapping Unlocks Autonomic Health

Discover how the new ANCHOR human brainstem atlas uses 3D brain mapping to revolutionize our understanding of autonomic health and neurodegeneration.

Photo-Theranostic Cleansing and Molecular Light: A New Paradigm for Clearing Misfolded Proteins in the Aging Brain

Explore how ADLumin-5 uses molecular light for clearing misfolded proteins and how engineered enzymes reverse protein glycation to combat biological aging.

Somatic Target Modulation and Epigenetic Methylation Metrics in Age Deceleration

Discover how clinical trials are using mTOR pathway inhibitors like sirolimus to prompt cellular cleanup, helping in preventing functional decline as we age.

Irina Timofte (ClinicalTrials.gov)PMID: clinicaltrials-NCT05237687ClinicalTrials.gov

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