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Proteomic Profiling and Machine Learning Models for Tracking Biological Skin Age

A new study uses machine learning to track biological skin age, revealing how topical bioactives shift key molecular profiles toward a younger state.

Communications biologyPMID: 41957170DOI
Neanderthal Growth Hormone Receptor: How Ancient DNA Shapes Muscle Mass Today

Discover how the Neanderthal growth hormone receptor variant remains active in modern humans, influencing muscle mass, skeletal features, and cellular aging.

How a New Peptide Targets Heart Stiffness to Prevent Heart Failure

A newly designed heart failure relaxation peptide targets cardiac stiffness at the subcellular level, preventing diastolic dysfunction in a mouse model with the potential to minimize off-target effects.

The Epigenetic Control of Hepatocellular Carcinoma Metabolism via the JMJD5-ISY1-PRMT6 Pathway

Discover how the JMJD5-ISY1-PRMT6 pathway regulates liver cancer metabolism, offering a novel precision medicine target for hepatocellular carcinoma.

Alzheimer's Tau Pathology: Why Human Neurons Are Uniquely Vulnerable

New research on Alzheimer's tau pathology reveals why human brain cells are uniquely vulnerable to damage, offering vital clues for cognitive longevity.

Why Do Some Liver Cells Double Their Genomes Safely?

How do hepatocytes survive whole-genome doubling? Learn how the latest research explains the cellular mechanics of healthy liver cell division.

Spatial Remodeling of the Bone Marrow Niche and CD8 T-Cell Expansion in Azacitidine Response

Discover how azacitidine alters the bone marrow microenvironment, driving CD8 T-cell expansion and reticular cell remodeling in myelodysplastic syndromes.

Reprogramming Protein Ligases for Genetic Code Expansion: How Chimeric Enzymes Enable Synthetic Protein Engineering

A groundbreaking study demonstrates genetic code expansion by reprogramming a bacterial protein ligase into a functional enzyme, enabling custom protein design.

How CAR T-Cell Therapy Solid Tumors Barriers Are Broken in Prostate Cancer

Evaluating how combining focal radiotherapy and CAR T-cell therapy solid tumors are dismantled, offering a new pathway for prostate cancer immunotherapy.

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